Characterization of rare NEIL1 variants found in East Asian populations.

ABSTRACT: The combination of chronic dietary exposure to the fungal toxin, aflatoxin B₁ (AFB₁), and hepatitis B viral (HBV) infection is associated with an increased risk for early onset hepatocellular carcinomas (HCCs). An in-depth knowledge of the mechanisms driving carcinogenesis is critical for the identification of genetic risk factors affecting the susceptibility of individuals who are HBV infected and AFB₁ exposed. AFB₁-induced mutagenesis is characterized by G to T transversions. Hence, the DNA repair pathways that function on AFB₁-induced DNA adducts or base damage from HBV-induced inflammation are anticipated to have a strong role in limiting carcinogenesis. These pathways define the mutagenic burden in the target tissues and ultimatel

SUBMITTER: Minko IG 

PROVIDER: S-EPMC6677271 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature