Automated analysis of soft hydrogel microindentation: Impact of various indentation parameters on the measurement of Young's modulus.

ABSTRACT: Measurements of Young's moduli are mostly evaluated using strong assumptions, such as sample homogeneity and isotropy. At the same time, descriptions of measurement parameters often lack detailed specifications. Many of these assumptions are, for soft hydrogels especially, not completely valid and the complexity of hydrogel microindentation demands more sophisticated experimental procedures in order to describe their elastic properties more accurately. We created an algorithm that automates indentation data analysis as a basis for the evaluation of large data sets with consideration of the influence of indentation depth on the measured Young's modulus. The algorithm automatically determines the Young's modulus in indentation regions where it becomes independent of the indentation depth and

SUBMITTER: Huth S 

PROVIDER: S-EPMC6677382 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature