Identifying Novel Types of Irritability Using a Developmental Genetic Approach.

ABSTRACT:

Objective

Irritability, which is strongly associated with impairment and negative outcomes, is a common reason for referral to mental health services but is a nosological and treatment challenge. A major issue is how irritability should be conceptualized. The authors used a developmental approach to test the hypothesis that there are several forms of irritability, including a "neurodevelopmental/ADHD-like" type, with onset in childhood, and a "depression/mood" type, with onset in adolescence.

Methods

Data were analyzed from the Avon Longitudinal Study of Parents and Children, a prospective U.K. population-based cohort. Irritability trajectory classes were estimated for 7,924 individuals with data at multiple time points across childhood and adolescence (four possible time po

SUBMITTER: Riglin L 

PROVIDER: S-EPMC6677571 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature