Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition.

ABSTRACT:

Background

Mammographic breast density declines during menopause. We assessed changes in volumetric breast density across the menopausal transition and factors that influence these changes.

Methods

Women without a history of breast cancer, who had full field digital mammograms during both pre- and postmenopausal periods, at least 2 years apart, were sampled from four facilities within the San Francisco Mammography Registry from 2007 to 2013. Dense breast volume (DV) was assessed using Volpara on mammograms across the time period. Annualized change in DV from pre- to postmenopause was estimated using linear mixed models adjusted for covariates and per-woman random effects. Multiplicative interactions were evaluated between premenopausal risk factors and time to determine whet

SUBMITTER: Engmann NJ 

PROVIDER: S-EPMC6677580 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature