Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments.

ABSTRACT: Proliferation of aberrant, dysfunctional lymphatic vessels around solid tumors is a common histologic finding. Studies have shown that abnormalities in lymphatic function result in accumulation of inflammatory cells with an immunosuppressive profile. We tested the hypothesis that dysfunctional lymphatic vessels surrounding solid tumors regulate changes in the tumor microenvironment and tumor-specific immune responses. Using subcutaneously implanted mouse melanoma and breast cancer tumors in a lymphatic endothelial cell-specific diphtheria toxin receptor transgenic mouse, we found that local ablation of lymphatic vessels increased peritumoral edema, as compared with controls. Comparative analysis of the peritumoral fluid demonstrated increases in the number of macrophages, CD4⁺ i

SUBMITTER: Kataru RP 

PROVIDER: S-EPMC6677612 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature