Pediatric Antibiotic-refractory Lyme Arthritis: A Multicenter Case-control Study.

ABSTRACT: OBJECTIVE:Few factors have consistently been linked to antibiotic-refractory Lyme arthritis (ARLA). We sought to identify clinical and treatment factors associated with pediatric ARLA. METHODS:We performed a case-control study in 3 pediatric rheumatology clinics in a Lyme-endemic region (2000-2013). Eligible children were aged ≤ 18 years with arthritis and had positive testing for Lyme disease by Western blot. Cases were 49 children with persistently active arthritis despite ≥ 8 weeks of oral antibiotics or ≥ 2 weeks of parenteral antibiotics; controls were 188 children whose arthritis resolved within 3 months of starting antibiotics. We compared preselected demographic, clinical, and treatment factors between groups using logistic regression. RESULTS:Characteristics positively associated

SUBMITTER: Horton DB 

PROVIDER: S-EPMC6677616 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature