Multimodal imaging reveals a complex pattern of dysfunction in corticolimbic pathways in major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor imaging (DTI) studies have failed to yield uniform results. In this context, examining key tracts and using information from multiple neuroimaging modalities may better characterize potential abnormalities in the MDD brain. This study analyzed data from 30 participants with MDD and 26 healthy participants who underwent DTI, magnetic resonance spectroscopy (MRS), resting-state functional magnetic resonance imaging (fMRI), and magnetoencephalography (MEG). Tracts connecting the

SUBMITTER: Nugent AC 

PROVIDER: S-EPMC6677619 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature