Canine parvovirus (CPV) phylogeny is associated with disease severity.

ABSTRACT: After its first identification in 1978, canine parvovirus (CPV) has been recognized all around the world as a major threat for canine population health. This ssDNA virus is characterized by a high substitution rate and several genetic and phenotypic variants emerged over time. Overall, the definition of 3 main antigenic variants was established based on specific amino acid markers located in a precise capsid position. However, the detection of several minor variants and incongruence observed between the antigenic classification and phylogeny have posed doubts on the reliability of this scheme. At the same time, CPV heterogeneity has favored the hypothesis of a differential virulence among variants, although no robust and consistent demonstration has been provided yet. The present study rej

SUBMITTER: Franzo G 

PROVIDER: S-EPMC6677720 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature