Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila.

ABSTRACT: The stereotyped arrangement of sensory bristles on the adult fly thorax arises from a self-organized process, in which inhibitory Notch signaling both delimits proneural stripes and singles out sensory organ precursor cells (SOPs). A dynamic balance between proneural factors and Enhancer of split-HLH (E(spl)-HLH) Notch targets underlies patterning, but how this is regulated is unclear. Here, were identify two classes of E(spl)-HLH factors, whose expression both precedes and delimits proneural activity, and is dependent on proneural activity and required for proper SOP spacing within the stripes, respectively. These two classes are partially redundant, since a member of the second class, that is normally cross-repressed by members of the first class, can functionally compensate for their ab

SUBMITTER: Couturier L 

PROVIDER: S-EPMC6677740 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature