Essential ion binding residues for Na⁺ flow in stator complex of the Vibrio flagellar motor.

ABSTRACT: The bacterial flagellar motor is a unique supramolecular complex which converts ion flow into rotational force. Many biological devices mainly use two types of ions, proton and sodium ion. This is probably because of the fact that life originated in seawater, which is rich in protons and sodium ions. The polar flagellar motor in Vibrio is coupled with sodium ion and the energy converting unit of the motor is composed of two membrane proteins, PomA and PomB. It has been shown that the ion binding residue essential for ion transduction is the conserved aspartic acid residue (PomB-D24) in the PomB transmembrane region. To reveal the mechanism of ion selectivity, we identified essential residues, PomA-T158 and PomA-T186, other than PomB-D24, in the Na⁺-driven flagellar motor. It has

SUBMITTER: Onoue Y 

PROVIDER: S-EPMC6677748 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature