Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.

ABSTRACT: The formation of new memories requires transcription. However, the mechanisms that limit signaling of relevant gene programs in space and time for precision of information coding remain poorly understood. We found that, during learning, the cellular patterns of expression of early response genes (ERGs) are regulated by class IIa HDACs 4 and 5, transcriptional repressors that transiently enter neuronal nuclei from cytoplasm after sensory input. Mice lacking these repressors in the forebrain have abnormally broad experience-dependent expression of ERGs, altered synaptic architecture and function, elevated anxiety, and severely impaired memory. By acutely manipulating the nuclear activity of class IIa HDACs in behaving animals using a chemical-genetic technique, we further demonstrate that ra

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC6677776 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature