Compartmental-modelling-based measurement of murine glomerular filtration rate using ¹⁸F-fluoride PET/CT.

ABSTRACT: Accurate measurement of glomerular filtration rate (GFR) is essential for optimal decision making in many clinical settings of renal failure. We aimed to show that GFR can be accurately measured using compartmental tracer kinetic analysis of ¹⁸F-fluoride dynamic PET/CT. Twenty-three male Sprague-Dawley rats of three experimental groups (cyclosporine-administered [n = 8], unilaterally nephrectomized [n = 8], and control [n = 7]) underwent simultaneous ¹⁸F-fluoride dynamic PET/CT and reference ⁵¹Cr-EDTA GFR (GFR_CrEDTA) test at day 0 and post-intervention day 3. ¹⁸F-fluoride PET GFR (GFR_F-PET) was calculated by multiplying the influx rate and functional kidney volume in a single-tissue-compartmental kinetic model. Within-test r

SUBMITTER: Lee HS 

PROVIDER: S-EPMC6677809 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature