Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity.

ABSTRACT: Hydrogen peroxide (H₂O₂) has a major function in host-microbial interactions. Although most studies have focused on the endogenous H₂O₂ produced by immune cells to kill microbes, bacteria can also produce H₂O₂. How microbial H₂O₂ influences the dynamics of host-microbial interactions is unclear. Here we show that H₂O₂ released by Streptococcus pneumoniae inhibits inflammasomes, key components of the innate immune system, contributing to the pathogen colonization of the host. We also show that the oral commensal H₂O₂-producing bacteria Streptococcus oralis can block inflammasome activation. This study uncovers an unexpected role of H₂O₂ in

SUBMITTER: Erttmann SF 

PROVIDER: S-EPMC6677825 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature