Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses.

ABSTRACT: Breast cancer is a highly heterogeneous disease. Although differences between intrinsic breast cancer subtypes have been well studied, heterogeneity within each subtype, especially luminal-A cancers, requires further interrogation to personalize disease management. Here, we applied well-characterized and cancer-associated heterocellular signatures representing stem, mesenchymal, stromal, immune, and epithelial cell types to breast cancer. This analysis stratified the luminal-A breast cancer samples into five subtypes with a majority of them enriched for a subtype (stem-like) that has increased stem and stromal cell gene signatures, representing potential luminal progenitor origin. The enrichment of immune checkpoint genes and other immune cell types in two (including stem-like) of the five

SUBMITTER: Poudel P 

PROVIDER: S-EPMC6677833 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature