Examining the identification of age-related atrophy between T1 and T1?+?T2-FLAIR cortical thickness measurements.

ABSTRACT: Cortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1?+?T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65-81 years, 48% females) that are part of an ongoing cohort study were analyzed to investigate whether T1?+?T2-FLAIR cortical thickness measurements were superior to those derived from T1-weighted images in identifying age-related atrophy. T1-weighted and T2-FLAIR MRI images were processed through FreeSurfer v6.0. Data was extracted using the Desikan-Killiany (DKT) atlas. FreeSurfer's GUI QDEC examined age-related atrophy. Nonparametric tests, effect sizes, and Pearson correlations examined differences between T1-only and T1?+?T2-FLAIR cortical thickness data. These analyses demonstrated that T1?+?T2-FLAIR processed images significantly improved the segmentation of gray matter (chi-square x2, p?

SUBMITTER: Lindroth H 

PROVIDER: S-EPMC6677836 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature