Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [¹⁸F]HX4 PET imaging study in colorectal cancer xenografts.

ABSTRACT:

Background

In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [¹⁸F]flortanidazole ([¹⁸F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential of [¹⁸F]HX4 as a predictive and/or prognostic biomarker within this setup.

Methods

Colo205-bearing mice (n = 40) underwent a baseline [¹⁸F]HX4 hypoxia μPET/computed tomography (CT) scan. The next day, mice received 100 mg/kg metformin or saline intravenously (n = 20/group) and [¹⁸F]HX4 was administered intravenously 30 min later, whereupon a second μPET/CT scan was performed to assess changes in tumor hypoxi

SUBMITTER: De Bruycker S 

PROVIDER: S-EPMC6677842 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature