An In Vitro Enrichment Strategy for Formulating Synergistic Synbiotics.

ABSTRACT: Research on the role of diet on gut and systemic health has led to considerable interest toward identifying novel therapeutic modulators of the gut microbiome, including the use of prebiotics and probiotics. However, various host responses have often been reported among many clinical trials. This is in part due to competitive exclusion as a result of the absence of ecological niches as well as host-mediated constraints via colonization resistance. In this research, we developed a novel in vitro enrichment (IVE) method for isolating autochthonous strains that can function as synergistic synbiotics and overcome these constraints. The method relied on stepwise in vitro fecal fermentations to enrich for and isolate Bifidobacterium strains that ferment the prebiotic xylooli

SUBMITTER: Kok CR 

PROVIDER: S-EPMC6677857 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature