Adapting a Plant Tissue Model to Animal Development: Introducing Cell Sliding into VirtualLeaf.

ABSTRACT: Cell-based, mathematical modeling of collective cell behavior has become a prominent tool in developmental biology. Cell-based models represent individual cells as single particles or as sets of interconnected particles and predict the collective cell behavior that follows from a set of interaction rules. In particular, vertex-based models are a popular tool for studying the mechanics of confluent, epithelial cell layers. They represent the junctions between three (or sometimes more) cells in confluent tissues as point particles, connected using structural elements that represent the cell boundaries. A disadvantage of these models is that cell-cell interfaces are represented as straight lines. This is a suitable simplification for epithelial tissues, where the interfaces are typically unde

SUBMITTER: Wolff HB 

PROVIDER: S-EPMC6677868 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature