Assessing genetic diversity and similarity of 435 KPC-carrying plasmids.

ABSTRACT: The global spread and diversification of multidrug-resistant Gram-negative (MRGN) bacteria poses major challenges to healthcare. In particular, carbapenem-resistant Klebsiella pneumoniae strains have been frequently identified in infections and hospital-wide outbreaks. The most frequently underlying resistance gene (bla_KPC) has been spreading over the last decade in the health care setting. bla_KPC seems to have rapidly diversified and has been found in various species and on different plasmid types. To review the progress and dynamics of this diversification, all currently available KPC plasmids in the NCBI database were analysed in this work. Plasmids were grouped into 257 different representative KPC plasmids, of which 79.4% could be clearly assigned to incompatibil

SUBMITTER: Brandt C 

PROVIDER: S-EPMC6677891 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature