Differential gene expression analysis reveals novel genes and pathways in pediatric septic shock patients.

ABSTRACT: Septic shock is a devastating health condition caused by uncontrolled sepsis. Advancements in high-throughput sequencing techniques have increased the number of potential genetic biomarkers under review. Multiple genetic markers and functional pathways play a part in development and progression of pediatric septic shock. We identified 53 differentially expressed pediatric septic shock biomarkers using gene expression data sampled from 181 patients admitted to the pediatric intensive care unit within the first 24 hours of their admission. The gene expression signatures showed discriminatory power between pediatric septic shock survivors and nonsurvivor types. Using functional enrichment analysis of differentially expressed genes, we validated the known genes and pathways in septic shock and

SUBMITTER: Mohammed A 

PROVIDER: S-EPMC6677896 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature