Re-positioning of known drugs for Pim-1 kinase target using molecular docking analysis.

ABSTRACT: The Concept of reusing existing drugs for new targets is gaining momentum in recent years because of cost-effectiveness as safety and toxicology data are already available. Therefore, it is of interest to re-profile known drugs against the Pim-1 kinase target using molecular docking analysis. Results show that known drugs such as nilotinib, vemurafenib, Idelalisib, and other small kinases inhibitors have high binding ability with Pim-1 kinase for consideration as potential inhibitors.

SUBMITTER: Arrouchi H 

PROVIDER: S-EPMC6677905 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature