Differential gene expression analysis in blood of first episode psychosis patients.

ABSTRACT:

Background

Psychosis is a condition influenced by an interaction of environmental and genetic factors. Gene expression studies can capture these interactions; however, studies are usually performed in patients who are in remission. This study uses blood of first episode psychosis patients, in order to characterise deregulated pathways associated with psychosis symptom dimensions.

Methods

Peripheral blood from 149 healthy controls and 131 first episode psychosis patients was profiled using Illumina HT-12 microarrays. A case/control differential expression analysis was performed, followed by correlation of gene expression with positive and negative syndrome scale (PANSS) scores. Enrichment analyses were performed on the associated gene lists. We test for pathway differences be

SUBMITTER: Leirer DJ 

PROVIDER: S-EPMC6677921 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature