Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study.

ABSTRACT:

Objective

We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).

Design

Three FADS variants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies.

Setting

Population based study.

Participants

11 323 women from the Nurses' Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women's Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS).

Mai

SUBMITTER: Huang T 

PROVIDER: S-EPMC6678013 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature