Multivariate genome-wide association study of rapid automatised naming and rapid alternating stimulus in Hispanic American and African-American youth.

ABSTRACT:

Background

Rapid automatised naming (RAN) and rapid alternating stimulus (RAS) are reliable predictors of reading disability. The underlying biology of reading disability is poorly understood. However, the high correlation among RAN, RAS and reading could be attributable to shared genetic factors that contribute to common biological mechanisms.

Objective

To identify shared genetic factors that contribute to RAN and RAS performance using a multivariate approach.

Methods

We conducted a multivariate genome-wide association analysis of RAN Objects, RAN Letters and RAS Letters/Numbers in a sample of 1331 Hispanic American and African-American youth. Follow-up neuroimaging genetic analysis of cortical regions associated with reading ability in an independent sample and epig

SUBMITTER: Truong DT 

PROVIDER: S-EPMC6678051 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature