Sex-Dimorphic Behavioral Alterations and Altered Neurogenesis in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.

ABSTRACT: Mutant mice with respect to the splicing factor Zrsr1 present altered spermatogenesis and infertility. To investigate whether Zrsr1 is involved in the homeostatic control that the hypothalamus exerts over reproductive functions, we first analyzed both differential gene and isoform expression and alternative splicing alterations in Zrsr1 mutant (Zrsr1^mu) hypothalamus; second, we analyzed the spontaneous and social behavior of Zrsr1^mu mice; and third, we analyzed adult cell proliferation and survival in the Zrsr1^mu hypothalamus. The Zrsr1^mu hypothalamus showed altered expression of genes and isoforms related to the glutathione metabolic process, synaptonemal complex assembly, mRNA transport, and alte

SUBMITTER: Alen F 

PROVIDER: S-EPMC6678158 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature