Human Aquaporin-5 Facilitates Hydrogen Peroxide Permeation Affecting Adaption to Oxidative Stress and Cancer Cell Migration.

ABSTRACT: Reactive oxygen species (ROS), including H₂O₂, contribute to oxidative stress and may cause cancer initiation and progression. However, at low concentrations, H₂O₂ can regulate signaling pathways modulating cell growth, differentiation, and migration. A few mammalian aquaporins (AQPs) facilitate H₂O₂ diffusion across membranes and participate in tumorigenesis. AQP3 and AQP5 are strongly expressed in cancer tissues and AQP3-mediated H₂O₂ transport has been related to breast cancer cell migration, but studies with human AQP5 are lacking. Here, we report that, in addition to its established water permeation capacity, human AQP5 facilitates transmembrane H₂O₂ diffusion and modulates ce

SUBMITTER: Rodrigues C 

PROVIDER: S-EPMC6678198 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature