Vasopressin in the Amelioration of Social Functioning in Autism Spectrum Disorder.

ABSTRACT: Autism spectrum disorder (ASD) is a developmental disability described by diagnostic criteria that comprise deficits in social communication and the existence of repetitive, restricted patterns of behavior, interests, or activities that can last throughout life. Many preclinical studies show the importance of arginine vasopressin (AVP) physiology in social functioning in several mammalian species. Currently, there is a trend to investigate more specific pharmacological agents to improve social functioning in patients with ASD. Neurobiological systems that are crucial for social functioning are the most encouraging conceivable signaling pathways for ASD therapeutic discovery. The AVP signaling pathway is one of the most promising. The purpose of this commentary is to detail the evidence on

SUBMITTER: Hendaus MA 

PROVIDER: S-EPMC6678231 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature