The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT₆ Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.

ABSTRACT: Among serotonin receptors, the 5-HT₆ subtype is the most controversial and the least known in the field of molecular mechanisms. The 5-HT₆R ligands can be pivotal for innovative treatment of cognitive impairment, but none has reached pharmacological market, predominantly, due to insufficient "druglikeness" properties. Recently, 1,3,5-triazine-piperazine derivatives were identified as a new chemical family of potent 5-HT₆R ligands. For the most active triazine 5-HT₆R agents found (1-4), a wider binding profile and comprehensive in vitro evaluation of their drug-like parameters as well as behavioral studies and an influence on body mass in vivo were investigated within this work. Results indicated the most promising pharmacological/dr

SUBMITTER: Latacz G 

PROVIDER: S-EPMC6678253 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature