Distribution of Killer-Cell Immunoglobulin-Like Receptor Genes and Combinations of Their Human Leucocyte Antigen Ligands in 11 Ethnic Populations in China.

ABSTRACT: The aim of this study was to analyze the distribution of killer-cell immunoglobulin-like receptor (KIR) genes and their human leucocyte antigen (HLA) ligand combinations in different original ethnic populations in China, and thus, to provide relevant genomic diversity data for the future study of viral infections, autoimmune diseases, and reproductive fitness. A total of 1119 unrelated individuals from 11 ethnic populations-including Hani, Jinuo, Lisu, Nu, Bulang, Wa, Dai, Maonan, Zhuang, Tu, and Yugu-from four original groups, were included. The presence/absence of the 16 KIR loci were detected, and the KIR gene's phenotype, genotype, and haplotype A and B frequencies, as well as KIR ligand's HLA allotype and KIR-HLA pairs for each population, were calculated. Principal component analysis

SUBMITTER: Yao Y 

PROVIDER: S-EPMC6678321 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature