CCR5 Promoter Polymorphism -2459G > A: Forgotten or Ignored?

ABSTRACT: C-C chemokine receptor 5 (CCR5) polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and -2459G > A in the promoter, are well known for their associations with HIV-1 infection and/or disease progression in a variety of studies. In this era of an HIV cure, where all the emphasis is on ∆32, it seems that -2459G > A has been forgotten or ignored. There is significant importance in the incorporation of the CCR5 -2459G > A genotype information into studies evaluating new immunologic and chemotherapeutic strategies, and those designing and implementing better treatment strategies with current antiretroviral therapy, doing so would enable a better understanding of the response to the intervention, due to a mechanistic or constitutive explanation. Until we find a str

SUBMITTER: Mehlotra RK 

PROVIDER: S-EPMC6678430 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature