Social Defeat Modulates T Helper Cell Percentages in Stress Susceptible and Resilient Mice.

ABSTRACT: Altered adaptive immunity involving T lymphocytes has been found in depressed patients and in stress-induced depression-like behavior in animal models. Peripheral T cells play important roles in homeostasis and function of the central nervous system and thus modulate behavior. However, the T cell phenotype and function associated with susceptibility and resilience to depression remain largely unknown. Here, we characterized splenic T cells in susceptible and resilient mice after 10 days of social defeat stress (SDS). We found equally decreased T cell frequencies and comparably altered expression levels of genes associated with T helper (Th) cell function in resilient and susceptible mice. Interleukin (IL)-17 producing CD4+ and CD8+ T cell numbers in the spleen were significantly increased

SUBMITTER: Ambree O 

PROVIDER: S-EPMC6678569 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature