Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer.

ABSTRACT: The thyroid is the most common site of endocrine cancer. One type of thyroid cancer, non-medullary thyroid cancer (NMTC), develops from follicular cells and represents approximately 90% of all thyroid cancers. Approximately 5%-15% of NMTC cases are thought to be of familial origin (FNMTC), which is defined as the occurrence of the disease in three or more first-degree relatives of the patient. It is often divided into two groups: Syndrome-associated and non-syndromic. The associated syndromes include Cowden syndrome, familial adenomatous polyposis, Gardner syndrome, Carney complex and Werner syndrome. The hereditary factors contributing to the unfavorable course of FNMTC remain poorly understood; therefore, considerable effort is being expended to identify contributing loci. Research carri

SUBMITTER: Hincza K 

PROVIDER: S-EPMC6678600 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature