Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naive Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12.

ABSTRACT: Chronic Lymphocytic Leukemia (CLL) patients with +12 have been reported to have specific clinical and biologic features. We performed an analysis of the association between demographic; clinical; laboratory; biologic features and outcome in CLL patients with +12 to identify parameters predictive of disease progression; time to treatment; and survival. The study included 487 treatment-naive CLL patients with +12 from 15 academic centers; diagnosed between January 2000 and July 2016; and 816 treatment-naïve patients with absence of Fluorescence In Situ Hybridization (FISH) abnormalities. A cohort of 250 patients with +12 CLL followed at a single US institution was used for external validation. In patients with +12; parameters associated with worse prognosis in the multivariate model were hig

SUBMITTER: Autore F 

PROVIDER: S-EPMC6678692 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature