Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network.

ABSTRACT: Diabetic retinopathy (DR) is reaching epidemic levels globally due to the increase in prevalence of diabetes mellitus (DM). DR also has detrimental effects to quality of life, as it is the leading cause of blindness in the working-age population and the most common cause of vision loss in individuals with DM. Over several decades, many studies have recognized the role of inflammation in the development and progression of DR; however, in recent years, accumulating evidence has also suggested that non-coding RNAs, especially long non-coding (lncRNAs), are aberrantly expressed in diabetes and may play a putative role in the development and progression of DR through the modulation of gene expression at the transcriptional, post-transcriptional, or epigenetic level. In this review, we will firs

SUBMITTER: Biswas S 

PROVIDER: S-EPMC6678747 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature