A Systematic Review of Phase II Targeted Therapy Clinical Trials in Anaplastic Thyroid Cancer.

ABSTRACT: Anaplastic thyroid carcinoma (ATC) is a rare, but devastating disease. Despite multimodal approaches combining surgery, chemotherapy and radiation therapy, ATC is associated with a dire prognosis, with a median overall survival of only three to ten months. Novel treatments are thus urgently needed. Recent efforts towards the characterization of the molecular landscape of ATC have led to the identification of pro-oncogenic targetable alterations, lending promise for novel targeted therapeutic approaches. This systematic review summarizes the results of phase II clinical trials of targeted therapy in ATC, providing an overview of efficacy and safety profiles. The majority of trials to date have consisted of small single-arm studies and have presented modest results. However, only a minority

SUBMITTER: Ljubas J 

PROVIDER: S-EPMC6678800 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature