Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer.

ABSTRACT: Detection of epithelial ovarian cancer (EOC) poses a critical medical challenge. However, novel biomarkers for diagnosis remain to be discovered. Therefore, innovative approaches are of the utmost importance for patient outcome. Here, we present a concept for blood-based biomarker discovery, investigating both epithelial and specifically stromal compartments, which have been neglected in search for novel candidates. We queried gene expression profiles of EOC including microdissected epithelium and adjacent stroma from benign and malignant tumours. Genes significantly differentially expressed within either the epithelial or the stromal compartments were retrieved. The expression of genes whose products are secreted yet absent in the blood of healthy donors were validated in tissue and blood

SUBMITTER: Kulbe H 

PROVIDER: S-EPMC6678810 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature