Motor Adaptation Impairment in Chronic Cannabis Users Assessed by a Visuomotor Rotation Task.

ABSTRACT: Background-The cerebellum has been recently suggested as an important player in the addiction brain circuit. Cannabis is one of the most used drugs worldwide, and its long-term effects on the central nervous system are not fully understood. No valid clinical evaluations of cannabis impact on the brain are available today. The cerebellum is expected to be one of the brain structures that are highly affected by prolonged exposure to cannabis, due to its high density in endocannabinoid receptors. We aim to use a motor adaptation paradigm to indirectly assess cerebellar function in chronic cannabis users (CCUs). Methods-We used a visuomotor rotation (VMR) task that probes a putatively-cerebellar implicit motor adaptation process together with the learning and execution of an explicit aiming ru

SUBMITTER: Herreros I 

PROVIDER: S-EPMC6678817 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature