Transcription Factors Indirectly Regulate Genes through Nuclear Colocalization.

ABSTRACT: Various types of data, including genomic sequences, transcription factor (TF) knockout data, TF-DNA interaction and expression profiles, have been used to decipher TF regulatory mechanisms. However, most of the genes affected by knockout of a particular TF are not bound by that factor. Here, I showed that this interesting result can be partially explained by considering the nuclear positioning of TF knockout affected genes and TF bound genes. I found that a statistically significant number of TF knockout affected genes show nuclear colocalization with genes bound by the corresponding TF. Although these TF knockout affected genes are not directly bound by the corresponding TF; the TF tend to be in the same cellular component with the TFs that directly bind these genes. TF knockout affected

SUBMITTER: Dai Z 

PROVIDER: S-EPMC6678861 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature