The Polymorphisms of the Peroxisome-Proliferator Activated Receptors' Alfa Gene Modify the Aerobic Training Induced Changes of Cholesterol and Glucose.

ABSTRACT:

Background

PPARα is a transcriptional factor that controls the expression of genes involved in fatty acid metabolism, including fatty acid transport, uptake by the cells, intracellular binding, and activation, as well as catabolism (particularly mitochondrial fatty acid oxidation) or storage. PPARA gene polymorphisms may be crucial for maintaining lipid homeostasis and in this way, being responsible for developing specific training-induced physiological reactions. Therefore, we have decided to check if post-training changes of body mass measurements as well as chosen biochemical parameters are modulation by the PPARA genotypes.

Methods

We have examined the genotype and alleles' frequencies (described in PPARA rs1800206 and rs4253778 polymorphic sites) in

SUBMITTER: Maciejewska-Skrendo A 

PROVIDER: S-EPMC6679124 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature