The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders.

ABSTRACT: Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various allergic diseases, including asthma (neutrophilic asthma and aspirin-sensitive asthma), allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and anaphylaxis. This review summarizes the biology of LTs and their receptors, recent developments in the area of anti-LT strategies (in settings such as ongoing clinical studies), and prospects for future therapeutic applications.

SUBMITTER: Jo-Watanabe A 

PROVIDER: S-EPMC6679143 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature