Platelets Are Critical Key Players in Sepsis.

ABSTRACT: Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet-pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.

SUBMITTER: Vardon-Bounes F 

PROVIDER: S-EPMC6679237 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature