Bone morphology is regulated modularly by global and regional genetic programs.

ABSTRACT: Bone protrusions provide stable anchoring sites for ligaments and tendons and define the unique morphology of each long bone. Despite their importance, the mechanism by which superstructures are patterned is unknown. Here, we identify components of the genetic program that control the patterning of Sox9⁺/Scx⁺ superstructure progenitors in mouse and show that this program includes both global and regional regulatory modules. Using light-sheet fluorescence microscopy combined with genetic lineage labeling, we mapped the broad contribution of the Sox9⁺/Scx⁺ progenitors to the formation of bone superstructures. Then, by combining literature-based evidence, comparative transcriptomic analysis and genetic mouse models, we id

SUBMITTER: Eyal S 

PROVIDER: S-EPMC6679367 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature