Modelling the MYC-driven normal-to-tumour switch in breast cancer.

ABSTRACT: The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we have generated an in vivo model that mimics human disease in response to MYC deregulation. MCF10A cells ectopically expressing a common breast cancer mutation in the phosphoinositide 3 kinase pathway (PIK3CA^H1047R) led to the development of organised acinar structures in mice. Expressing both PIK3CA^H1047R and deregulated MYC led to the development of invasive ductal carcinoma. Therefore, the deregulation of MYC expression in this setting creates a MYC-dependent normal-to-tumour switch that can be measured in vivo These MYC-driven tumours exh

SUBMITTER: Lourenco C 

PROVIDER: S-EPMC6679384 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature