Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling.

ABSTRACT:

Background

Mammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a potential anticancer agent in various types of human cancer. However, there are no reports evaluating the antitumor effects of ivermectin in canine mammary tumor. Here, we investigated whether ivermectin was able to inhibit canine mammary tumor development and explored the related mechanisms.

Results

Ivermectin inhibited the growth of canine mammary tumor cell lines in a dose- and time-dependent manner. The antitumor effects induced by ivermectin were associated with cell cycle arrest at G1 phase via down-regulation of CDK4 and cyclin D1 expression, with no signi

SUBMITTER: Diao H 

PROVIDER: S-EPMC6679554 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature