Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca²⁺ signaling.

ABSTRACT: Acidic organelles, such as endosomes and lysosomes, store Ca²⁺ that is released in response to intracellular increases in the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP). In neurons, NAADP and Ca²⁺ signaling contribute to synaptic plasticity, a process of activity-dependent long-term potentiation (LTP) [or, alternatively, long-term depression (LTD)] of synaptic strength and neuronal transmission that is critical for neuronal function and memory formation. We explored the function of and mechanisms regulating acidic Ca²⁺ store signaling in murine hippocampal neurons. We found that metabotropic glutamate receptor 1 (mGluR1) was coupled to NAADP signaling that elicited Ca²⁺ release from acidic stores. In turn, this release

SUBMITTER: Foster WJ 

PROVIDER: S-EPMC6679716 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature