A genome-wide association study-derived polygenic score for interleukin-1β is associated with hippocampal volume in two samples.

ABSTRACT: Accumulating research suggests that the pro-inflammatory cytokine interleukin-1β (IL-1β) has a modulatory effect on the hippocampus, a brain structure important for learning and memory as well as linked with both psychiatric and neurodegenerative disorders. Here, we used an imaging genetics strategy to test an association between an IL-1β polygenic score and hippocampal volume in two independent samples. Our polygenic score was derived using summary statistics from a recent genome-wide association study of circulating cytokines that included IL-1β (N = 3,309). In the first sample of 512 non-Hispanic Caucasian university students (274 women, mean age 19.78 ± 1.24 years) from the Duke Neurogenetics Study, we identified a significant positive correlation between IL-1β polygenic scores and hip

SUBMITTER: Avinun R 

PROVIDER: S-EPMC6679724 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature