Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage.

ABSTRACT:

Background

Deletions encompassing a four-gene region on chromosome 15 (BP1-BP2 at 15q11.2), seen at a population frequency of 1 in 500, are associated with increased risk for schizophrenia, epilepsy, and other common neurodevelopmental disorders. However, little is known in terms of how these common deletions impact cognition.

Methods

We used a Web-based tool to characterize cognitive function in a novel cohort of adult carriers and their noncarrier family members. Results from 31 carrier and 38 noncarrier parents from 40 families were compared with control data from 6530 individuals who self-registered on the Lumosity platform and opted in to participate in research. We then examined aspects of sensory and cognitive function in flies harboring a mutation in Cyfip, the homol

SUBMITTER: Woo YJ 

PROVIDER: S-EPMC6679746 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature