Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.

ABSTRACT: Several studies that have identified agents that potentiate the antimicrobial activity of antibiotics, but there are limited insights into their structure-activity relationships (SAR). The SAR associated with select N-alkylaryl amide derivatives of ornithine was performed to establish those structural features that were associated with potentiation of the antimicrobial activity of clarithromycin against E. coli ATCC 25922. The data indicate that the N-propyl derivative was slightly more active in reducing the effective MIC of clarithromycin against E. coli ATCC 25922. In addition, the S-enantiomer of compound 9 was somewhat more potent than the R-enantiomer in potentiating clarithromycin activity. No significant enhancement in potentiation activity was observed with the conversion of these

SUBMITTER: Blankson G 

PROVIDER: S-EPMC6679755 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature