Quantitative assessment of cortical somatosensory digit representations after median and ulnar nerve injury in rats.

ABSTRACT: Incomplete recovery of sensory function is common after peripheral nerve injury (PNI). Despite reinnervation following injury, disorganized cortical representations persist and may contribute to functional deficits. There is a dearth of literature characterizing cortical responses after PNI in rodent models. Here we develop a quantitative electrophysiological method for mapping forepaw digit responses in primary somatosensory cortex (S1) of rats. We tested the hypothesis that PNI in the forelimb would generate significant, long lasting sensory deficits, and corresponding disorganization in S1. Rats underwent a transection of the proximal segment of the median and ulnar nerves in the forelimb followed by tubular repair. 4-12 months after nerve injury, we tested mechanosensory withdrawal thr

SUBMITTER: Hulsey DR 

PROVIDER: S-EPMC6679757 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature