Intraarticular Glucocorticoid Injection as Second-line Treatment for Lyme Arthritis in Children.

ABSTRACT:

Objective

To determine whether second-line intraarticular glucocorticoid (IAGC) injection improves outcomes in children with persistently active Lyme arthritis after initial antibiotics.

Methods

We conducted an observational comparative effectiveness study through chart review within 3 pediatric rheumatology centers with distinct clinical approaches to second-line treatment of Lyme arthritis. We primarily compared children receiving second-line IAGC to children receiving a second course of antibiotics alone. We evaluated the risk of developing antibiotic-refractory Lyme arthritis (ARLA) using logistic regression and the time to clinical resolution of Lyme arthritis using Cox regression.

Results

Of 112 children with persistently active Lyme arthritis after first-line a

SUBMITTER: Horton DB 

PROVIDER: S-EPMC6679761 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature